Indomethacin: Uses and Benefits

Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and joint stiffness. It works by reducing hormones that cause inflammation. Doctors often prescribe it for arthritis, gout, bursitis, and tendonitis. It may also help with other conditions as directed by a healthcare provider.

How Indomethacin Works

This medication inhibits prostaglandin production, chemicals responsible for pain and swelling. By blocking these compounds, indomethacin reduces discomfort and improves mobility. It is available in oral capsules, suppositories, and injectable forms for different treatment needs.

Common Dosage Guidelines

Dosage varies based on the condition being treated. For arthritis, adults typically take 25-50 mg two to three times daily. Acute gout may require higher short-term doses. Always follow medical advice to avoid side effects like stomach ulcers or kidney issues.

Potential Side Effects

Indomethacin may cause dizziness, stomach pain, or heartburn. Serious effects include black stools, chest pain, or liver problems. Patients with heart disease or high blood pressure should use caution. Report any unusual symptoms to a doctor immediately.

Precautions and Warnings

Avoid alcohol and other NSAIDs while taking indomethacin to prevent stomach bleeding. Elderly patients and those with kidney disease need adjusted doses. Inform your doctor about all medications, including blood thinners or diuretics, before use.

Storage and Handling

Store at room temperature away from moisture. Keep capsules in their original container and discard expired medication safely. Do not share indomethacin with others, even if they have similar symptoms.

Indomethacin for Gout Relief

Indomethacin is highly effective for acute gout attacks, reducing pain within hours. It decreases uric acid crystal-induced inflammation. Treatment usually lasts 5-7 days. Long-term gout management may require additional medications like allopurinol.

Comparing Indomethacin to Other NSAIDs

Unlike ibuprofen, indomethacin has stronger anti-inflammatory effects, making it better for severe conditions. However, it carries a higher risk of side effects. Naproxen may be safer for long-term use in some patients.

Indomethacin in Pregnancy

This drug is not recommended during pregnancy, especially in the third trimester, due to risks to the fetus. It may cause premature ductus arteriosus closure. Always consult an OB-GYN before using NSAIDs while pregnant.

Drug Interactions to Avoid

Indomethacin can increase lithium or methotrexate toxicity. Combining it with blood pressure medications may reduce their effectiveness. Always disclose your full medication list to prevent dangerous interactions.

Alternatives to Indomethacin

For patients who cannot tolerate indomethacin, alternatives include celecoxib or diclofenac. Physical therapy or corticosteroid injections may also help. Discuss options with your healthcare provider for personalized advice.

Long-Term Use Considerations

Prolonged indomethacin use requires regular monitoring for kidney or liver damage. Doctors may recommend periodic blood tests. If chronic pain persists, explore other treatment strategies to minimize risks.

What Conditions Does Indomethacin Treat?

Indomethacin treats arthritis, gout, bursitis, and tendonitis. It also helps with ankylosing spondylitis and patent ductus arteriosus in premature infants.

How Quickly Does Indomethacin Work?

For gout or arthritis, pain relief may begin within 1-2 hours. Full anti-inflammatory effects can take days to weeks with regular use.

Can Indomethacin Cause Stomach Ulcers?

Yes, long-term use increases ulcer risk. Taking it with food or using proton pump inhibitors can help protect the stomach lining.

Is Indomethacin Safe for Elderly Patients?

Elderly patients are more prone to side effects. Lower doses and close monitoring are recommended to avoid kidney or gastrointestinal issues.

What Should I Do If I Miss a Dose?

Take it as soon as you remember, unless it’s close to the next dose. Never double doses to compensate for a missed one.

Can Indomethacin Be Taken With Alcohol?

No, alcohol increases the risk of stomach bleeding. Avoid drinking while using this or any NSAID.

Does Indomethacin Raise Blood Pressure?

Yes, NSAIDs like indomethacin can elevate blood pressure. Hypertensive patients should use it cautiously under medical supervision.

What’s the Difference Between Indomethacin and Ibuprofen?

Indomethacin is stronger and used for severe inflammation. Ibuprofen is milder and available over-the-counter for general pain relief.

Can I Take Indomethacin Before Surgery?

No, stop taking it at least 7 days before surgery to reduce bleeding risks. Follow your surgeon’s instructions.

Are There Natural Alternatives to Indomethacin?

Turmeric, ginger, and omega-3s have anti-inflammatory properties but may not replace prescription NSAIDs for severe conditions.